Purpose: The detection of the association of serum magnesium on mortality and morbidity in Heart Failure patients.
Methods: The selection of the studies was based on searching in the databases, Pubmed and Scopus. The assessment of the quality of the selected studies was accomplished according to validated quality criteria in prognostic studies (QUIPS tool).
Results: Eight studies were considered appropriate for participating in the systematic review, which include 8651 Heart Failure patients with low LVEF (left ventricular ejection fraction). In half of studies, hypomagnesemia is considered to be independent prognostic factor for cardiovascular mortality, including sudden death. Only in one study did magnesium levels >2.4 mg/dl constitute independent prognostic factor for all-cause mortality, whilst there was no statistical association between serum magnesium and morbidity outcomes in Heart Failure patients.
Conclusion: Heart failure patients who develop hypomagnesemia at heightened risk of increased cardiovascular mortality, including sudden death.
Heart failure, Magnesium, Mortality, Morbidity